Wednesday, 27 April 2011

Karidium




In the US, Karidium (fluoride systemic) is a member of the drug class minerals and electrolytes.

US matches:

  • Karidium Drops

  • Karidium

Ingredient matches for Karidium



Clobazam

Clobazam is reported as an ingredient of Karidium in the following countries:


  • Argentina

International Drug Name Search

Desvenlafaxine Extended-Release Tablets


Pronunciation: des-VEN-la-FAX-een
Generic Name: Desvenlafaxine
Brand Name: Pristiq

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Desvenlafaxine Extended-Release Tablets outweigh the risks.


Family and caregivers must closely watch patients who take Desvenlafaxine Extended-Release Tablets. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.





Desvenlafaxine Extended-Release Tablets are used for:

Treating depression. It may also be used for other conditions as determined by your doctor.


Desvenlafaxine Extended-Release Tablets are a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by restoring the balance of certain natural substances in the brain (serotonin and norepinephrine), which helps to improve certain mood problems.


Do NOT use Desvenlafaxine Extended-Release Tablets if:


  • you are allergic to any ingredient in Desvenlafaxine Extended-Release Tablets or to venlafaxine

  • you are taking or have taken linezolid, methylene blue, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or St. John's wort within the last 14 days

  • you are taking a fenfluramine derivative (eg, dexfenfluramine), nefazodone, sibutramine, or tryptophan

  • you are taking another medicine that contains venlafaxine or desvenlafaxine

Contact your doctor or health care provider right away if any of these apply to you.



Video: Treatment for Depression







Treatments for depression are getting better everyday and there are things you can start doing right away.






Before using Desvenlafaxine Extended-Release Tablets:


Some medical conditions may interact with Desvenlafaxine Extended-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse

  • if you have a history of seizures, heart problems (eg, heart failure, irregular heartbeat), a heart attack, an abnormal electrocardiogram (ECG), a recent heart attack, a stroke or bleeding in the brain, blood or bleeding problems, or high blood pressure

  • if you have a history of high cholesterol or triglycerides, liver problems, lung problems, kidney problems, stomach or bowel bleeding, or increased eye pressure (eg, glaucoma)

  • if you are dehydrated, have low blood sodium levels, low blood volume, or drink alcohol

  • if you will be having electroconvulsive therapy (ECT)

Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Certain diet medicines (eg, fenfluramine, phentermine), linezolid, lithium, MAOIs (eg, phenelzine), methylene blue, metoclopramide, nefazodone, rasagiline, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), selegiline, serotonin 5-HT1 receptor agonists (eg, sumatriptan), sibutramine, SNRIs (eg, duloxetine), St. John's wort, tramadol, trazodone, tricyclic antidepressants (eg, amitriptyline), or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur

  • Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding, including stomach bleeding, may be increased

  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased

  • Azole antifungals (eg, ketoconazole) because they may increase the risk of Desvenlafaxine Extended-Release Tablets's side effects

  • Cyproheptadine because it may decrease Desvenlafaxine Extended-Release Tablets's effectiveness

  • Desipramine or midazolam because the risk of their side effects may be increased by Desvenlafaxine Extended-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Desvenlafaxine Extended-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Desvenlafaxine Extended-Release Tablets:


Use Desvenlafaxine Extended-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Desvenlafaxine Extended-Release Tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Desvenlafaxine Extended-Release Tablets refilled.

  • Take Desvenlafaxine Extended-Release Tablets by mouth with or without food.

  • Swallow Desvenlafaxine Extended-Release Tablets whole with fluid. Do not break, crush, chew, or dissolve before swallowing.

  • Take Desvenlafaxine Extended-Release Tablets at about the same time each day.

  • Continue to take Desvenlafaxine Extended-Release Tablets even if you feel well. Do not miss any doses.

  • Do not suddenly stop taking Desvenlafaxine Extended-Release Tablets without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, abnormal dreams, diarrhea, dizziness, drowsiness, confusion, headache, increased sweating, nausea, ringing in the ears, seizures, tremor, trouble sleeping, or unusual tiredness. You will be closely monitored when you start Desvenlafaxine Extended-Release Tablets and whenever a change in dose is made.

  • If you miss a dose of Desvenlafaxine Extended-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Desvenlafaxine Extended-Release Tablets.



Important safety information:


  • Desvenlafaxine Extended-Release Tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Desvenlafaxine Extended-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Desvenlafaxine Extended-Release Tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these side effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

  • Do not drink alcohol while you are using Desvenlafaxine Extended-Release Tablets.

  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Desvenlafaxine Extended-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

  • Several weeks may pass before your symptoms get better. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • You may notice the tablet shell in your stool. This is normal and not a cause for concern.

  • Children, teenagers, and young adults who take Desvenlafaxine Extended-Release Tablets may be at increased risk of suicidal thoughts or actions. Watch all patients who take Desvenlafaxine Extended-Release Tablets closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

  • Serotonin syndrome is a possibly fatal syndrome that can be caused by Desvenlafaxine Extended-Release Tablets. Your risk may be greater if you take Desvenlafaxine Extended-Release Tablets with certain other medicines (eg, "triptans," MAOIs, SSRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.

  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Desvenlafaxine Extended-Release Tablets. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

  • If your doctor tells you to stop taking Desvenlafaxine Extended-Release Tablets, you will need to wait for a period of time before beginning to take certain other medicines (eg, MAOIs, nefazodone). Ask your doctor when you should start to take your new medicines after you have stopped taking Desvenlafaxine Extended-Release Tablets.

  • Lab tests, including blood cholesterol and triglyceride levels, and blood pressure, may be performed while you use Desvenlafaxine Extended-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

  • Use Desvenlafaxine Extended-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sodium levels.

  • Caution is advised when using Desvenlafaxine Extended-Release Tablets in CHILDREN; they may be more sensitive to its effects, especially increased risk of suicidal thoughts or actions.

  • Desvenlafaxine Extended-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: Desvenlafaxine Extended-Release Tablets may cause harm to the fetus if it is used during the last 3 months of pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Desvenlafaxine Extended-Release Tablets while you are pregnant. Desvenlafaxine Extended-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use Desvenlafaxine Extended-Release Tablets, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Desvenlafaxine Extended-Release Tablets:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; fatigue; flushing; headache; increased sweating; loss of appetite; nausea; stomach upset; trouble sleeping; vomiting; yawning.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); behavior changes; blood in the stools; blurred vision; chest pain or discomfort; confusion; decreased concentration; decreased coordination; decreased urination; enlarged pupils; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; memory problems; new or worsening agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, restlessness, or inability to sit still; new or worsening mental or mood changes; red, swollen, blistered, or peeling skin; seizures; severe or persistent cough; severe or persistent headache, dizziness, or stomach pain; severe or persistent trouble sleeping; shortness of breath; significant weight loss; suicidal thoughts or attempts; tremor; unusual bruising or bleeding; unusual weakness; worsening of depression.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Desvenlafaxine side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; coma; dilated pupils; fainting; fast, slow, or irregular heartbeat; muscle pain or weakness; numbness or tingling; seizures; severe or persistent diarrhea, nausea, or vomiting; severe or persistent dizziness, drowsiness, headache, or trouble breathing; vomiting; yellowing of the eyes or skin.


Proper storage of Desvenlafaxine Extended-Release Tablets:

Store Desvenlafaxine Extended-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Desvenlafaxine Extended-Release Tablets out of the reach of children and away from pets.


General information:


  • If you have any questions about Desvenlafaxine Extended-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.

  • Desvenlafaxine Extended-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Desvenlafaxine Extended-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Desvenlafaxine resources


  • Desvenlafaxine Side Effects (in more detail)
  • Desvenlafaxine Dosage
  • Desvenlafaxine Use in Pregnancy & Breastfeeding
  • Desvenlafaxine Drug Interactions
  • Desvenlafaxine Support Group
  • 451 Reviews for Desvenlafaxine - Add your own review/rating


Compare Desvenlafaxine with other medications


  • ADHD
  • Anxiety
  • Bipolar Disorder
  • Depression
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  • Hot Flashes
  • Narcolepsy
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  • Obesity
  • Panic Disorder
  • Post Traumatic Stress Disorder
  • Postmenopausal Symptoms

Sunday, 24 April 2011

Fortaz


Fortaz is a brand name of ceftazidime, approved by the FDA in the following formulation(s):


FORTAZ (ceftazidime - injectable; injection)



  • Manufacturer: GLAXOSMITHKLINE

    Approval date: July 19, 1985

    Strength(s): 1GM/VIAL [RLD][AP], 2GM/VIAL [RLD][AP], 500MG/VIAL [RLD][AP], 6GM/VIAL [RLD][AP]

Has a generic version of Fortaz been approved?


Yes. The following products are equivalent to Fortaz:


ceftazidime injectable; injection



  • Manufacturer: ACS DOBFAR

    Approval date: November 20, 1985

    Strength(s): 1GM/VIAL [AP], 2GM/VIAL [AP], 500MG/VIAL [AP]


  • Manufacturer: ACS DOBFAR

    Approval date: February 3, 1992

    Strength(s): 6GM/VIAL [AP]


  • Manufacturer: AUROBINDO PHARMA

    Approval date: May 28, 2010

    Strength(s): 1GM/VIAL [AP], 2GM/VIAL [AP], 500MG/VIAL [AP], 6GM/VIAL [AP]


  • Manufacturer: WOCKHARDT

    Approval date: October 15, 2008

    Strength(s): 1GM/VIAL [AP]

TAZICEF (ceftazidime injectable; injection)



  • Manufacturer: HOSPIRA

    Approval date: March 6, 1986

    Strength(s): 1GM/VIAL [AP], 2GM/VIAL [AP], 500MG/VIAL [AP], 6GM/VIAL [AP]


  • Manufacturer: HOSPIRA

    Approval date: October 31, 1993

    Strength(s): 1GM/VIAL [AP], 2GM/VIAL [AP]

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Fortaz. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.




Related Patents

There are no current U.S. patents associated with Fortaz.

See also...

  • Fortaz Consumer Information (Wolters Kluwer)
  • Fortaz Consumer Information (Cerner Multum)
  • Fortaz Advanced Consumer Information (Micromedex)
  • Fortaz AHFS DI Monographs (ASHP)
  • Ceftazidime Consumer Information (Wolters Kluwer)
  • Ceftazidime injection Consumer Information (Cerner Multum)
  • Ceftazidime Injection Advanced Consumer Information (Micromedex)
  • Ceftazidime AHFS DI Monographs (ASHP)

Thursday, 21 April 2011

Dilaudid


Generic Name: hydromorphone (Oral route)

hye-droe-MOR-fone

Oral route(Tablet;Liquid)

Hydromorphone is a potent Schedule II opioid agonist, which has the highest potential for abuse and risk of producing respiratory depression. Alcohol, other opioids and central nervous system depressants (sedative-hypnotics) potentiate the respiratory depressant effects of hydromorphone, increasing the risk of respiratory depression that might result in death .


Oral route(Tablet, Extended Release)

Exalgo(R) is a potent Schedule II opioid agonist, which has the highest potential for abuse and risk of respiratory depression. Hydromorphone extended-release tablets (Exalgo(R)) are for use in opioid-tolerant patients only with moderate to severe chronic pain. Use in non-opioid-tolerant patients may lead to fatal respiratory depression. Exalgo(R) is for continuous analgesia only and is not intended for use on an as needed basis (ie, PRN). Exalgo(R) should be swallowed whole; not broken, chewed, opened, dissolved, or crushed .



Commonly used brand name(s)

In the U.S.


  • Dilaudid

  • Dilaudid-5

  • Exalgo

  • Palladone

Available Dosage Forms:


  • Liquid

  • Tablet, Extended Release

  • Capsule, Extended Release

  • Tablet

  • Solution

Therapeutic Class: Analgesic


Chemical Class: Opioid


Uses For Dilaudid


Hydromorphone oral liquid and tablets are used to relieve pain. The hydromorphone extended-release tablets are used to relieve moderate to severe pain in opioid-tolerant patients.


Hydromorphone belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.


When a narcotic medicine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped. completely.


This medicine is available only with your doctor's prescription.


Before Using Dilaudid


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of hydromorphone in the pediatric population. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydromorphone in the elderly. However, elderly patients may be more sensitive to the effects of hydromorphone than younger adults, and are more likely to have age-related lung, liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving hydromorphone.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.


  • Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Adinazolam

  • Alfentanil

  • Alprazolam

  • Amobarbital

  • Anileridine

  • Aprobarbital

  • Aripiprazole

  • Brofaromine

  • Bromazepam

  • Brotizolam

  • Buprenorphine

  • Buspirone

  • Butabarbital

  • Butalbital

  • Butorphanol

  • Carisoprodol

  • Chloral Hydrate

  • Chlordiazepoxide

  • Chlorpromazine

  • Chlorzoxazone

  • Clobazam

  • Clonazepam

  • Clorazepate

  • Clorgyline

  • Clozapine

  • Codeine

  • Dantrolene

  • Desflurane

  • Dexmedetomidine

  • Dezocine

  • Diazepam

  • Diphenhydramine

  • Doxylamine

  • Enflurane

  • Estazolam

  • Eszopiclone

  • Ethchlorvynol

  • Fentanyl

  • Flumazenil

  • Flunitrazepam

  • Fluphenazine

  • Flurazepam

  • Fospropofol

  • Furazolidone

  • Halazepam

  • Haloperidol

  • Halothane

  • Hydrocodone

  • Hydromorphone

  • Hydroxyzine

  • Iproniazid

  • Isocarboxazid

  • Isoflurane

  • Ketamine

  • Ketazolam

  • Lazabemide

  • Levorphanol

  • Linezolid

  • Lorazepam

  • Lormetazepam

  • Loxapine

  • Medazepam

  • Meperidine

  • Mephenesin

  • Mephobarbital

  • Meprobamate

  • Mesoridazine

  • Metaxalone

  • Methocarbamol

  • Methohexital

  • Midazolam

  • Moclobemide

  • Molindone

  • Morphine

  • Morphine Sulfate Liposome

  • Nalbuphine

  • Nialamide

  • Nitrazepam

  • Nitrous Oxide

  • Nordazepam

  • Olanzapine

  • Opium

  • Oxazepam

  • Oxycodone

  • Oxymorphone

  • Paliperidone

  • Pargyline

  • Pentazocine

  • Pentobarbital

  • Perphenazine

  • Phenelzine

  • Phenobarbital

  • Pimozide

  • Prazepam

  • Procarbazine

  • Promazine

  • Promethazine

  • Propofol

  • Propoxyphene

  • Quazepam

  • Quetiapine

  • Ramelteon

  • Rasagiline

  • Remifentanil

  • Risperidone

  • Secobarbital

  • Selegiline

  • Sevoflurane

  • Sodium Oxybate

  • Sufentanil

  • Tapentadol

  • Temazepam

  • Thiopental

  • Thioridazine

  • Thiothixene

  • Toloxatone

  • Tranylcypromine

  • Triazolam

  • Trifluoperazine

  • Zaleplon

  • Ziprasidone

  • Zolpidem

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.


  • Ethanol

Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Addison's disease (adrenal gland problem) or

  • Alcohol abuse, or history of or

  • Breathing or lung problems (e.g., chronic obstructive pulmonary disease [COPD], cor pulmonale, hypercapnia, hypoxia, sleep apnea) or

  • CNS depression, history of or

  • Drug dependence, especially narcotic abuse or dependence, history of or

  • Enlarged prostate (BPH, prostatic hypertrophy) or

  • Gallbladder disease or

  • Hypothyroidism (an underactive thyroid) or

  • Kyphoscoliosis (curvature of spine that can cause breathing problems) or

  • Mental illness, or history of or

  • Obesity, severe or

  • Problems with passing urine—Use with caution. May increase risk for more serious side effects.

  • Brain tumor or

  • Head injuries or

  • Increased pressure in your head—Some of the side effects of hydromorphone can cause serious problems in people who have these medical problems.

  • Breathing problems (e.g., asthma, hypercapnia), severe or

  • Respiratory depression (hypoventilation or slow breathing)—Should not be used in patients with these conditions.

  • Gallbladder surgery or

  • Hypotension (low blood pressure) or

  • Pancreatitis (inflammation of the pancreas) or

  • Seizures, history of—Use with caution. May make these conditions worse.

  • Kidney disease or

  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

  • Not opioid-tolerant (if you are not already taking a certain amount of morphine, oxycodone, or other opioid medicine) or

  • Paralytic ileus (intestinal blockage) or

  • Stomach or bowel problems (e.g., narrowing of the intestines, Meckel's diverticulum, peritonitis, "short gut" syndrome), history of or

  • Surgery (e.g., stomach, intestinal), history of or

  • Trouble with swallowing—Exalgo® extended-release tablets should not be given in patients with these conditions.

  • Stomach or digestion problems—This medicine may mask the diagnosis of these conditions.

Proper Use of hydromorphone

This section provides information on the proper use of a number of products that contain hydromorphone. It may not be specific to Dilaudid. Please read with care.


Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).


Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.


If you are using the extended-release tablets:


  • Hydromorphone extended-release tablets are for use in opioid-tolerant patients only. If you are uncertain whether or not you are opioid-tolerant, check with your doctor before using this medicine.

  • This medicine comes with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

  • Swallow the tablets whole. Do not break, crush, or chew it.

  • While taking this medicine, part of the tablet may pass into your stools. This is normal and is nothing to worry about.

Exalgo® tablets works differently than hydromorphone tablets, even at the same dose (number of milligrams). Do not switch from the extended-release tablets to the immediate-release tablets unless your doctor tells you to.


Be careful not to handle crushed or broken tablets. If you have contact with broken or crushed tablets or spilled oral liquid, wash your skin or the affected areas with soap and water right away.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (extended-release tablets):
    • For moderate to severe pain:
      • For patients switching from other oral hydromorphone to Exalgo®:
        • Adults—The once daily starting dose is the same as the total hydromorphone dose that you are taking daily. Your doctor may increase the dose every 3 to 4 days as needed.

        • Children—Use and dose must be determined by your doctor.


      • For patients switching from oral opioids to Exalgo®:
        • Adults—At first, the dose is half of the total opioid dose that you are taking every 24 hours. Your doctor may increase the dose as needed.

        • Children—Use and dose must be determined by your doctor.


      • For patients switching from fentanyl transdermal to Exalgo®:
        • Adults—The medicine should be started at least 18 hours after the removal of the fentanyl patch. At first, the dose is 12 mg every 24 hours for each 25 microgram per hour (mcg/hr) of the transdermal fentanyl. Your doctor may increase the dose as needed.

        • Children—Use and dose must be determined by your doctor.




  • For oral dosage form (liquid):
    • For pain:
      • Adults—At first, 2.5 to 10 milliliters (mL) or one-half to two teaspoonfuls every 3 to 6 hours as needed . Your doctor may increase your dose as needed.

      • Children—Use and dose must be determined by your doctor.



  • For oral dosage form (tablets):
    • For pain:
      • Adults—At first, 2 to 4 milligrams (mg) every 4 to 6 hours. Your doctor may increase your dose as needed.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Flush the unused medicine down the toilet.


Precautions While Using Dilaudid


It is very important that your doctor check your progress while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.


This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the other medicines listed above while you are using this medicine.


This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.


Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve dizziness or lightheadedness.


Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.


This medicine may make you dizzy, drowsy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.


This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.


If you have been using this medicine regularly for several weeks or more, do not change your dose or suddenly stop using it without first checking with your doctor. You may be directed to gradually reduce the amount you are using before stopping treatment completely, or to take another narcotic for a while, to lessen the chance of withdrawal side effects (such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping).


Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your child has the following symptoms: abnormal sleep pattern, diarrhea, high-pitched cry, irritability, shakiness or tremor, weight loss, vomiting, or failure to gain weight.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.


Dilaudid Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Less common or rare
  • Agitation

  • bloody, black, or tarry stools

  • blurred vision

  • changes in behavior

  • chest pain or discomfort

  • convulsions

  • decreased urination

  • dry mouth

  • fast, pounding, or irregular heartbeat or pulse

  • lightheadedness, dizziness, or fainting

  • mood or mental changes

  • rapid breathing

  • severe stomach pain, cramping, or burning

  • severe vomiting

  • shortness of breath

  • slow or irregular heartbeat

  • stiff neck

  • sunken eyes

  • thoughts of killing oneself

  • trouble breathing

  • unusual tiredness

  • vomiting of material that looks like coffee grounds, severe and continuing

  • wrinkled skin

Incidence not known
  • Bluish lips or skin

  • change in the ability to see colors, especially blue or yellow

  • cold, clammy skin

  • confusion

  • cough

  • decrease in the frequency of urination

  • decrease in urine volume

  • difficulty in passing urine (dribbling)

  • difficult or troubled breathing

  • dizziness

  • fast, weak pulse

  • headache

  • heart stops

  • irregular, fast or slow, or shallow breathing

  • loss of appetite

  • no pulse or blood pressure

  • noisy breathing

  • not breathing

  • painful urination

  • pale or blue lips, fingernails, or skin

  • sleeplessness

  • sweating

  • tightness in the chest

  • trouble sleeping

  • unable to sleep

  • unconscious

  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Decreased awareness or responsiveness

  • increased sensitivity of the eyes to light

  • no muscle tone or movement

  • sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Difficulty having a bowel movement (stool)

  • difficulty with moving

  • muscle pain or stiffness

  • nausea

  • pain in the joints

Less common
  • Acid or sour stomach

  • back pain

  • belching

  • bloating or swelling of the face, arms, hands, lower legs, or feet

  • diarrhea

  • discouragement

  • feeling sad or empty

  • heartburn

  • indigestion

  • irritability

  • loss of interest or pleasure

  • muscle spasms

  • pain in the arms or legs

  • rapid weight gain

  • stomach discomfort, upset, or pain

  • tingling of the hands or feet

  • trouble concentrating

  • unusual weight gain or loss

  • weight loss

Less common or rare
  • Being forgetful

  • bleeding after defecation

  • change in taste

  • changes in the patterns and rhythms of speech

  • clumsiness

  • continuing ringing or buzzing or other unexplained noise in the ears

  • crying

  • decreased interest in sexual intercourse

  • delusions of persecution, mistrust, suspiciousness, or combativeness

  • difficulty with swallowing

  • difficulty with walking

  • double vision

  • excess air or gas in the stomach or intestines

  • extra heartbeats

  • feeling of constant movement of self or surroundings

  • full feeling

  • hearing loss

  • inability to have or keep an erection

  • increased appetite

  • joint pain, stiffness, or swelling

  • loss in sexual ability, desire, drive, or performance

  • loss of balance

  • loss of taste

  • low body temperature

  • muscle aches

  • muscle twitching or jerking

  • overactive reflexes

  • passing gas

  • rhythmic movement of muscles

  • runny nose

  • seeing double

  • seeing, hearing, or feeling things that are not there

  • sensation of spinning

  • shivering

  • slurred speech

  • sneezing

  • swelling of the feet or lower legs

  • trouble with speaking

  • uncomfortable swelling around the anus

  • weak or feeble pulse

Incidence not known
  • Bad, unusual or unpleasant (after)taste

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

  • chills

  • constricted, pinpoint, or small pupils (black part of the eye)

  • deep or fast breathing with dizziness

  • drowsiness

  • dry mouth

  • false or unusual sense of well-being

  • fear or nervousness

  • feeling of warmth

  • hives or welts

  • muscle stiffness or tightness

  • numbness of the feet, hands, and around the mouth

  • redness of the skin

  • redness of the face, neck, arms, and occasionally, upper chest

  • relaxed and calm

  • shaking

  • skin itching

  • uncontrolled eye movements

  • upper abdominal or stomach pain

  • weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Dilaudid side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Dilaudid resources


  • Dilaudid Side Effects (in more detail)
  • Dilaudid Use in Pregnancy & Breastfeeding
  • Drug Images
  • Dilaudid Drug Interactions
  • Dilaudid Support Group
  • 136 Reviews for Dilaudid - Add your own review/rating


  • Dilaudid Prescribing Information (FDA)

  • Dilaudid MedFacts Consumer Leaflet (Wolters Kluwer)

  • Dilaudid Consumer Overview

  • Dilaudid-HP MedFacts Consumer Leaflet (Wolters Kluwer)

  • Dilaudid-HP Prescribing Information (FDA)

  • Exalgo Consumer Overview

  • Exalgo Prescribing Information (FDA)

  • Exalgo MedFacts Consumer Leaflet (Wolters Kluwer)

  • Hydromorphone Prescribing Information (FDA)

  • Hydromorphone Hydrochloride Monograph (AHFS DI)

  • Palladone Prescribing Information (FDA)

  • Palladone Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Dilaudid with other medications


  • Cough
  • Pain

Tuesday, 19 April 2011

desmopressin



Generic Name: desmopressin (oral) (DEZ mo press in)

Brand Names: DDAVP


What is desmopressin?

Desmopressin is a man-made form of a hormone that occurs naturally in the pituitary gland. This hormone is important for many functions including blood flow, blood pressure, kidney function, and regulating how the body uses water.


Desmopressin is used to treat bed-wetting, central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma.


Desmopressin may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about oral desmopressin?


It is very important to reduce your intake of water and other fluids while you are taking desmopressin. Drinking too much water can cause your body to lose sodium, which may lead to a serious, life-threatening electrolyte imbalance.

Fluid restriction is especially important in children and older adults taking desmopressin. Follow your doctor's instructions about the type and amount of liquids you should drink.


You should not use this medication if you have severe kidney disease or if you have ever had hyponatremia (low sodium levels in your body).

Before taking desmopressin, tell your doctor if you have heart disease, coronary artery disease, congestive heart failure, kidney disease, cystic fibrosis, high or low blood pressure, an electrolyte imbalance, or a psychological disorder that causes extreme or unusual thirst.


To be sure desmopressin is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with this medication. Do not miss any scheduled appointments.


What should I discuss with my healthcare provider before taking oral desmopressin?


You should not take this medication if you are allergic to desmopressin, or if you have:

  • severe kidney disease; or




  • if you have ever had hyponatremia (low sodium levels in your body).



Before taking desmopressin, tell your doctor if you are allergic to any medications, or if you have:



  • heart disease, coronary artery disease;




  • congestive heart failure;




  • kidney disease;




  • cystic fibrosis;




  • high or low blood pressure;




  • an electrolyte imbalance; or




  • a psychologic disorder that causes extreme or unusual thirst.



If you have any of these conditions, you may need a dose adjustment or special tests to safely take desmopressin.


FDA pregnancy category B. This medication is not expected to harm an unborn baby. Do not use desmopressin without telling your doctor if you are pregnant. It is not known whether desmopressin passes into breast milk, or if it could harm a nursing baby. Do not use desmopressin without telling your doctor if you are breast-feeding a baby.

How should I take desmopressin?


Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.


It is very important to reduce your intake of water and other fluids while you are taking desmopressin. Drinking too much water can cause your body to lose sodium, which may lead to a serious, life-threatening electrolyte imbalance.

Fluid restriction is especially important in children and older adults taking desmopressin. Follow your doctor's instructions about the type and amount of liquids you should drink.


If you are switching from desmopressin nasal spray to desmopressin tablets, wait at least 24 hours after your last nasal dose before you take your first tablet.

To be sure this medication is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with desmopressin. Do not miss any scheduled appointments.


Store the tablets at room temperature away from moisture, light, and heat.

See also: Desmopressin dosage (in more detail)

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include headache, confusion, drowsiness, rapid weight gain, or urination problems.


What should I avoid while taking desmopressin?


Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking desmopressin.


Desmopressin side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking desmopressin and call your doctor at once if you have any of these serious side effects:

  • nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;




  • feeling like you might pass out;




  • swelling, weight gain; or




  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).



Less serious side effects may include:



  • headache;




  • nausea, mild stomach pain;




  • diarrhea; or




  • warmth, redness, or tingly feeling in your face.



This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.


Desmopressin Dosing Information


Usual Adult Dose for Diabetes Insipidus:

Initial dose: 0.05 mg orally twice a day or
1 to 2 mcg IV twice a day or
1 to 2 mcg subcutaneously twice a day or
5 to 40 mcg spray intranasally twice a day or
0.1 to 0.4 mL via rhinal tube intranasally twice a day.
The optimal dosage depends on the patient's response (duration of sleep and adequate, not excessive water turnover). The morning and evening doses should be separately adjusted for an adequate diurnal rhythm of water turnover.

Usual Adult Dose for Hemophilia A:

IV: 0.3 mcg/kg once slowly over 15-30 minutes. Preoperative IV doses may be given 30 minutes prior to scheduled procedure. Blood pressure and heart rate monitoring during infusion is recommended. Repeat administration should be determined by laboratory response as well as the clinical condition of the patient.
Intranasal: 1 spray (1.5 mg/mL) in each nostril one time.
Demonstration of an adequate improvement in coagulation profile after administration is recommended prior to any surgical procedures. Preoperative doses may be given 2 hours prior to the scheduled procedure. Repeat administration should be determined by laboratory response and clinical condition of the patient.

Usual Adult Dose for von Willebrand's Disease:

IV: 0.3 mcg/kg once slowly over 15-30 minutes. Preoperative IV doses may be given 30 minutes prior to scheduled procedure. Blood pressure and heart rate monitoring during infusion is recommended. Repeat administration should be determined by laboratory response as well as the clinical condition of the patient.
Intranasal: 1 spray (1.5 mg/mL) in each nostril one time.
Demonstration of an adequate improvement in coagulation profile after administration is recommended prior to any surgical procedures. Preoperative doses may be given 2 hours prior to the scheduled procedure. Repeat administration should be determined by laboratory response and clinical condition of the patient. The nasal spray should not be used to treat patients with type IIB von Willebrand's disease since platelet aggregation may be induced.

Usual Adult Dose for Primary Nocturnal Enuresis:

Oral: 0.2 to 0.6 mg once before bedtime.

Usual Pediatric Dose for Diabetes Insipidus:

Infants 3 months of age to children 12 years of age:
Intranasal: 5 mcg/day as a single dose or in 2 divided doses. Dose range is 5 to 30 mcg/day. The morning and evening doses should be separately adjusted for an adequate diurnal rhythm of water turnover.
Oral: 0.05 mg twice a day. Dose range is 0.1 to 0.8 mg daily.
IV and subcutaneously: No definitive dosing available. Adult dosing should not be used in this age group; adverse events such as hyponatremia-induced seizures may occur. Dose should be reduced. Some have suggested an initial dosage range of 0.1 to 1 mcg in 1 or 2 divided doses. Initiate at low dose and increase as necessary. Closely monitor serum sodium levels and urine output; fluid restriction is recommended.

Children more than 12 years of age:
Intranasal: 5 to 40 mcg/day divided into 1 to 3 doses. The morning and evening doses should be separately adjusted for an adequate diurnal rhythm of water turnover.
Oral: 0.05 mg twice daily. Dose range is 0.1 to 1.2 mg divided into 2 or 3 doses.
IV: 1 to 2 mcg twice a day
Subcutaneously: 1 to 2 mcg twice a day

Use in children requires careful fluid intake restrictions to prevent possible hyponatremia and water intoxication. The optimal dosage depends on the patient's response (duration of sleep and adequate, not excessive water turnover).

Usual Pediatric Dose for Hemophilia A:

Infants 3 months of age and children:
IV: 0.3 mcg/kg by slow infusion over 15-30 minutes beginning 30 minutes before procedure. May repeat dose if needed.

Children more than 12 years of age:
IV: 0.3 mcg/kg once slowly over 15-30 minutes.
Intranasal:
50 kg or less: 150 mcg
more than 50 kg: 150 mcg in each nostril.
Demonstration of an adequate improvement in coagulation profile after administration is recommended prior to any surgical procedures. Preoperative doses may be given 2 hours prior to the scheduled procedure. Repeat administration should be determined by laboratory response and clinical condition of the patient.

Usual Pediatric Dose for von Willebrand's Disease:

Infants 3 months of age and children:
IV: 0.3 mcg/kg by slow infusion over 15 to 30 minutes beginning 30 minutes before procedure. May repeat dose if needed.

Children more than 12 years of age:
IV: 0.3 mcg/kg once slowly over 15 to 30 minutes.
Intranasal:
50 kg or less: 150 mcg
More than 50 kg: 150 mcg in each nostril.
Demonstration of an adequate improvement in coagulation profile after administration is recommended prior to any surgical procedures. Preoperative doses may be given 2 hours prior to the scheduled procedure. Repeat administration should be determined by laboratory response and clinical condition of the patient. The nasal spray should not be used to treat patients with type IIB von Willebrand's disease since platelet aggregation may be induced.

Usual Pediatric Dose for Primary Nocturnal Enuresis:

6 years or older:
0.2 to 0.6 mg orally once daily before bedtime.


What other drugs will affect desmopressin?


Many drugs can interact with desmopressin. Below is just a partial list. Tell your doctor if you are using:



  • carbamazepine (Carbatrol, Tegretol);




  • chlorpromazine (Thorazine);




  • lamotrigine (Lamictal);




  • oxybutynin (Ditropan, Urotrol, Oxytrol);




  • vasopressin (Pitressin);




  • a narcotic pain medicine such as fentanyl (Actiq, Duragesic), hydrocodone (Lortab, Vicodin), oxycodone (Oxycontin), and others;




  • an "SSRI" antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft);




  • a tricyclic antidepressant such as amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), and others;




  • medicine to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);




  • drugs to treat high blood pressure or a prostate disorder, such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax);




  • a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta, Ziac), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), or timolol (Blocadren); or




  • an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), and others.



This list is not complete and there may be other drugs that can interact with desmopressin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.



More desmopressin resources


  • Desmopressin Side Effects (in more detail)
  • Desmopressin Dosage
  • Desmopressin Use in Pregnancy & Breastfeeding
  • Drug Images
  • Desmopressin Drug Interactions
  • Desmopressin Support Group
  • 15 Reviews for Desmopressin - Add your own review/rating


  • desmopressin Nasal, Oral, Injection Advanced Consumer (Micromedex) - Includes Dosage Information

  • Desmopressin MedFacts Consumer Leaflet (Wolters Kluwer)

  • Desmopressin Prescribing Information (FDA)

  • DDAVP Prescribing Information (FDA)

  • Desmopressin Acetate Monograph (AHFS DI)

  • Minirin Spray MedFacts Consumer Leaflet (Wolters Kluwer)

  • Stimate Prescribing Information (FDA)

  • Stimate Spray MedFacts Consumer Leaflet (Wolters Kluwer)



Compare desmopressin with other medications


  • Diabetes Insipidus
  • Hemophilia A
  • Primary Nocturnal Enuresis
  • von Willebrand's Disease


Where can I get more information?


  • Your pharmacist can provide more information about desmopressin.

See also: desmopressin side effects (in more detail)


Adco-Zopimed




Adco-Zopimed may be available in the countries listed below.


Ingredient matches for Adco-Zopimed



Eszopiclone

Zopiclone is reported as an ingredient of Adco-Zopimed in the following countries:


  • South Africa

International Drug Name Search

Dimetapp Cold & Cough


Generic Name: brompheniramine, dextromethorphan, and phenylephrine (brome fen IR a meen, dex troe metho OR fan, fen il EFF rin)

Brand Names: Alacol DM, Alahist DM, BP Allergy DM, BPM PE DM, Bromatan-DM, Bromtuss DM, BroveX PEB DM, Children's Cold & Cough DM, Cold & Cough Childrens, Dimaphen DM, Dimetapp Cold & Cough, Dimetapp DM Cold & Cough, DuraTan DM, Duravent DPB, Lohist-DM, Lortuss DM (obsolete), Tusdec-DM


What is Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.


Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


Brompheniramine, dextromethorphan, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.


Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.


Brompheniramine, dextromethorphan, and phenylephrine may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?


Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Brompheniramine, dextromethorphan, and phenylephrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

What should I discuss with my healthcare provider before taking Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?


Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking this medication, tell your doctor if you are allergic to brompheniramine, dextromethorphan, or phenylephrine, or if you have:


  • kidney disease;

  • liver disease;


  • diabetes;




  • glaucoma;




  • heart disease or high blood pressure;




  • diabetes;




  • a thyroid disorder;




  • a stomach ulcer or a stomach obstruction,




  • emphysema or chronic bronchitis; or




  • an enlarged prostate or urination problems.



If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.


FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Brompheniramine, dextromethorphan, and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cough-and-cold medications may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.


How should I take Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?


Use this medication exactly as directed on the label or as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.


Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.


Take this medicine with food or milk if it upsets your stomach.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.


Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.


Store the medication at room temperature away from moisture and heat.

What happens if I miss a dose?


Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).


What should I avoid while taking Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?


This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

Avoid using other medicines that make you sleepy (such as sleeping pills, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine, dextromethorphan, and phenylephrine.


Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.


Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;




  • confusion, hallucinations, unusual thoughts or behavior;




  • severe dizziness, anxiety, restless feeling, or nervousness;




  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);




  • confusion, hallucinations, unusual thoughts or behavior;




  • slow, shallow breathing;




  • urinating less than usual or not at all;




  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or




  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).



Less serious side effects may include:



  • blurred vision;




  • dry mouth;




  • nausea, stomach pain, constipation;




  • mild loss of appetite, stomach upset;




  • warmth, tingling, or redness under your skin;




  • sleep problems (insomnia);




  • restless or excitability (especially in children);




  • skin rash or itching;




  • dizziness, drowsiness;




  • problems with memory or concentration; or




  • ringing in your ears.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?


Before taking this medication, tell your doctor if you are using any of the following drugs:



  • an antidepressant;




  • a diuretic (water pill);




  • medication to treat irritable bowel syndrome;




  • celecoxib (Celebrex);




  • cinacalcet (Sensipar);




  • darifenacin (Enablex);




  • imatinib (Gleevec);




  • quinidine (Quinaglute, Quinidex);




  • ranolazine (Ranexa)




  • ritonavir (Norvir);




  • sibutramine (Meridia);




  • terbinafine (Lamisil);




  • medicines to treat high blood pressure;




  • aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);




  • bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); or




  • a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.



This list is not complete and there may be other drugs that can interact with brompheniramine, dextromethorphan, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More Dimetapp Cold & Cough resources


  • Dimetapp Cold & Cough Side Effects (in more detail)
  • Dimetapp Cold & Cough Use in Pregnancy & Breastfeeding
  • Dimetapp Cold & Cough Drug Interactions
  • 0 Reviews for Dimetapp Cold & Cough - Add your own review/rating


  • Alacol DM Elixir MedFacts Consumer Leaflet (Wolters Kluwer)

  • Bromatan-DM Suspension MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Dimetapp Cold & Cough with other medications


  • Cough and Nasal Congestion


Where can I get more information?


  • Your pharmacist can provide more information about brompheniramine, dextromethorphan, and phenylephrine.

See also: Dimetapp Cold & Cough side effects (in more detail)


Dequazol




Dequazol may be available in the countries listed below.


Ingredient matches for Dequazol



Metronidazole

Metronidazole is reported as an ingredient of Dequazol in the following countries:


  • Peru

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Pardelprin




Pardelprin may be available in the countries listed below.


UK matches:

  • Pardelprin MR
  • Pardelprin MR Capsules 75mg (SPC)

Ingredient matches for Pardelprin



Indometacin

Indometacin is reported as an ingredient of Pardelprin in the following countries:


  • United Kingdom

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SPC Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Myolaxin




Myolaxin may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Myolaxin



Guaifenesin

Guaifenesin is reported as an ingredient of Myolaxin in the following countries:


  • France

  • Germany

  • Sweden

  • Switzerland

  • United Kingdom

International Drug Name Search

Friday, 15 April 2011

Diazepam Intensol


Generic Name: diazepam (Oral route)

dye-AZ-e-pam

Commonly used brand name(s)

In the U.S.


  • Diazepam Intensol

  • Valium

Available Dosage Forms:


  • Tablet

  • Solution

  • Capsule, Extended Release

Therapeutic Class: Antianxiety


Pharmacologic Class: Benzodiazepine, Long Acting


Uses For Diazepam Intensol


Diazepam is used to relieve symptoms of anxiety and alcohol withdrawal. This medicine may also be used to treat certain seizure disorders and help relax muscles or relieve muscle spasm.


Diazepam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.


This medicine is available only with your doctor's prescription.


Before Using Diazepam Intensol


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of diazepam in infants below 6 months of age. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of diazepam in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving diazepam.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Alfentanil

  • Amobarbital

  • Anileridine

  • Aprobarbital

  • Buprenorphine

  • Butabarbital

  • Butalbital

  • Carisoprodol

  • Chloral Hydrate

  • Chlorzoxazone

  • Codeine

  • Dantrolene

  • Ethchlorvynol

  • Etravirine

  • Fentanyl

  • Fospropofol

  • Hydrocodone

  • Hydromorphone

  • Itraconazole

  • Ketorolac

  • Levorphanol

  • Meperidine

  • Mephenesin

  • Mephobarbital

  • Meprobamate

  • Metaxalone

  • Methocarbamol

  • Methohexital

  • Morphine

  • Morphine Sulfate Liposome

  • Naproxen

  • Oxycodone

  • Oxymorphone

  • Pentobarbital

  • Phenobarbital

  • Primidone

  • Propoxyphene

  • Remifentanil

  • Secobarbital

  • Sodium Oxybate

  • Sufentanil

  • Tapentadol

  • Thiopental

  • Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Amitriptyline

  • Amprenavir

  • Clarithromycin

  • Dalfopristin

  • Disulfiram

  • Erythromycin

  • Fluvoxamine

  • Ginkgo

  • Isoniazid

  • Mirtazapine

  • Phenytoin

  • Quinupristin

  • Rifapentine

  • Roxithromycin

  • St John's Wort

  • Theophylline

  • Troleandomycin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.


  • Grapefruit Juice

Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Alcohol abuse, or history of, or

  • Drug abuse or dependence, or history of—Dependence on diazepam may develop.

  • Breathing problems or lung disease, severe or

  • Glaucoma, narrow-angle or

  • Liver disease, severe or

  • Myasthenia gravis or

  • Sleep apnea (temporary stopping of breathing during sleep)—Should not be used in patients with these conditions.

  • Depression, or history of—Use with caution. May make this condition worse.

  • Kidney disease or

  • Liver disease, mild or moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of diazepam

This section provides information on the proper use of a number of products that contain diazepam. It may not be specific to Diazepam Intensol. Please read with care.


Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.


To use the oral solution:


  • Measure the oral liquid with the medicine dropper from the package.

  • Mix each dose with water, juice, soda or a soda-like beverage before you take it. You may also mix the liquid with a semisolid food such as applesauce or pudding.

  • Take the entire mixture right away. It should not be saved to use later.

Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (tablets or solution):
    • For anxiety:
      • Adults—2 to 10 milligrams (mg) two to four times per day.

      • Older adults—At first, 2 to 2.5 milligrams (mg) once or twice per day. Your doctor may gradually increase the dose if needed.

      • Children 6 months of age and older—At first, 1 to 2.5 milligrams (mg) three or four times per day. Your child's doctor may increase the dose if needed.

      • Infants below 6 months of age—Use and dose must be determined by your doctor.


    • For alcohol withdrawal:
      • Adults—10 milligrams (mg) three or four times for the first 24 hours, then 5 mg three to four times per day as needed.

      • Older adults—At first, 2 to 2.5 milligrams (mg) once or twice per day. Your doctor may gradually increase the dose if needed.

      • Children—Use and dose must be determined by your doctor.


    • For muscle spasm:
      • Adults—2 to 10 milligrams (mg) three or four times per day.

      • Older adults—At first, 2 to 2.5 milligrams (mg) once or twice per day. Your doctor may gradually increase the dose if needed.

      • Children 6 months of age and older—At first, 1 to 2.5 milligrams (mg) three or four times per day. Your child's doctor may increase the dose if needed.

      • Infants below 6 months of age—Use and dose must be determined by your doctor.


    • For seizures:
      • Adults—2 to 10 milligrams (mg) two to four times per day.

      • Older adults—At first, 2 to 2.5 milligrams (mg) once or twice per day. Your doctor may gradually increase the dose if needed.

      • Children 6 months of age and older—At first, 1 to 2.5 milligrams (mg) three or four times per day. Your child's doctor may increase the dose if needed.

      • Infants below 6 months of age—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Destroy any medicine that you do not need by flushing it down the toilet.


Precautions While Using Diazepam Intensol


It is very important that your doctor check the progress of you or your child at regular visits to see if the medicine is working properly. Blood tests may be needed to check for any unwanted effects.


Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.


This medicine may cause some people, especially older persons, to become drowsy, dizzy, lightheaded, clumsy, unsteady, or less alert than they are normally. Also, this medicine may cause double vision or other vision problems. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.


This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you or your child stop taking this medicine. Check with your doctor before taking any of the above while you or your child are using this medicine.


If you or your child develop any unusual or strange thoughts and behavior while taking diazepam, be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.


Do not stop taking this medicine without checking with your doctor first. Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.


Diazepam Intensol Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Shakiness and unsteady walk

  • unsteadiness, trembling, or other problems with muscle control or coordination

Incidence not known
  • Abdominal or stomach pain

  • agitation

  • anxiety

  • black, tarry stools

  • blistering, flaking, or peeling of skin

  • blurred vision

  • changes in patterns and rhythms of speech

  • chills

  • confusion

  • cough

  • dark urine

  • decrease in frequency of urination

  • decrease in urine volume

  • difficulty in passing urine (dribbling)

  • discouragement

  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

  • false beliefs that cannot be changed by facts

  • fast heartbeat

  • fast or irregular breathing

  • feeling sad or empty

  • feeling that others are watching you or controlling your behavior

  • feeling that others can hear your thoughts

  • feeling, seeing, or hearing things that are not there

  • fever

  • headache

  • hyperexcitability

  • increased muscle spasms or tone

  • irritability

  • itching

  • lack of appetite

  • lack of memory of what takes place after a certain event

  • loss of appetite

  • loss of bladder control

  • loss of interest or pleasure

  • lower back or side pain

  • mood or other mental changes

  • nausea

  • nervousness

  • nightmares

  • outbursts of anger

  • painful or difficult urination

  • pale skin

  • rash

  • restlessness

  • seizures

  • shakiness in the legs, arms, hands, or feet

  • shortness of breath

  • sleeplessness

  • slurred speech

  • sore throat

  • sweating

  • trembling or shaking of the hands or feet

  • tremor

  • trouble concentrating

  • trouble in speaking

  • trouble sleeping

  • ulcers, sores, or white spots in the mouth

  • unable to sleep

  • unpleasant breath odor

  • unusual behavior

  • unusual bleeding or bruising

  • unusual feeling of excitement

  • unusual tiredness or weakness

  • vomiting of blood

  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Change in consciousness

  • difficult or troubled breathing

  • irregular, fast or slow, or shallow breathing

  • lack of coordination

  • loss of consciousness

  • loss of strength or energy

  • muscle pain or weakness

  • pale or blue lips, fingernails, or skin

  • sleepiness

  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Incidence not known
  • Constipation

  • decreased interest in sexual intercourse

  • diarrhea

  • difficulty in swallowing

  • double vision

  • dry mouth

  • feeling of constant movement of self or surroundings

  • inability to have or keep an erection

  • increase in sexual ability, desire, drive, or performance

  • increased interest in sexual intercourse

  • increased watering of mouth

  • indigestion

  • loss of sexual ability, desire, drive, or performance

  • passing of gas

  • seeing double

  • sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Diazepam Intensol side effects (in more detail)



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More Diazepam Intensol resources


  • Diazepam Intensol Side Effects (in more detail)
  • Diazepam Intensol Use in Pregnancy & Breastfeeding
  • Diazepam Intensol Drug Interactions
  • Diazepam Intensol Support Group
  • 0 Reviews for Diazepam Intensol - Add your own review/rating


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